Sodium Hydroxide → Lomerizine

HRID 977925

반응식

HRID 977925 반응식
Cl.Cl.[CH3:3][O:4][C:5]1[C:32]([O:33][CH3:34])=[C:31]([O:35][CH3:36])[CH:30]=[CH:29][C:6]=1[CH2:7][N:8]1[CH2:13][CH2:12][N:11]([CH:14]([C:22]2[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=2)[C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)[CH2:10][CH2:9]1.[OH-].[Na+]>>[CH3:3][O:4][C:5]1[C:32]([O:33][CH3:34])=[C:31]([O:35][CH3:36])[CH:30]=[CH:29][C:6]=1[CH2:7][N:8]1[CH2:9][CH2:10][N:11]([CH:14]([C:22]2[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=2)[C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)[CH2:12][CH2:13]1

참가 물질

3

반응물 2

HCID 14798Sodium HydroxideHCID 122125Lomerizine Hydrochloride

생성물 1

HCID 3949Lomerizine수율 64.2%

실험 절차

The 1-(2,3,4-trimethoxybenzyl)-4-[bis(4-fluorophenyl)methyl]piperazine dihydrochloride obtained in Example 4 (20.0 g; 36.9 millimoles) was added to 100 ml of a 20% aqueous solution of sodium hydroxide. The resulting oily product was extracted with 100 ml of ethyl acetate. The ethyl acetate layer was dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give 11.1 g of 1-(2,3,4-trimethoxybenzyl)-4-[bis(4-fluorophenyl)methyl]piperazine as an oil.

후처리

  1. extractionThe resulting oily product was extracted with 100 ml of ethyl acetate
  2. dry with materialThe ethyl acetate layer was dried over anhydrous magnesium sulfate
  3. customThe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-bd78c94178324c7cb3f7b4d19a91315c
출처 데이터셋
uspto-grants-1987_05
특허 번호
US04663325

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