1,3-dimethyl-4-nitro-1H-pyrazole-5-carboxamide → 4-amino-1,3-dimethyl-1H-pyrazole-5-carboxamide

HRID 977933

반응식

HRID 977933 반응식
[CH3:1][N:2]1[C:6]([C:7]([NH2:9])=[O:8])=[C:5]([N+:10]([O-])=O)[C:4]([CH3:13])=[N:3]1>CO.[Ni]>[CH3:1][N:2]1[C:6]([C:7]([NH2:9])=[O:8])=[C:5]([NH2:10])[C:4]([CH3:13])=[N:3]1

참가 물질

4

반응물 1

HCID 12297641,3-dimethyl-4-nitro-1H-pyrazole-5-carboxamide

생성물 1

HCID 138229254-amino-1,3-dimethyl-1H-pyrazole-5-carboxamide

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

Fifty grams of 1,3-dimethyl-4-nitro-pyrazole-5-carboxamide as prepared in Preparation 2 is dissolved in methanol, 2 g 50% of Raney nickel is added, and the compound is reduced under a hydrogen atmosphere until a 8.15 pound drop in pressure noted. The reaction mixture was filtered, the filtrate concentrated, and the crude material recrystallized in ethyl acetate to yield the product, 1,3-dimethyl-4-amino-pyrazol-5-carboxamide mp 154°-155° C.

후처리

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate concentrated
  3. customthe crude material recrystallized in ethyl acetate

출처 및 근거

ORD 기록
ord-341396783bff4a27abde78b65bb22670
출처 데이터셋
uspto-grants-1987_05
특허 번호
US04663326

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