Diazomethane → Methyl 3-methoxy-1-benzothiophene-2-carboxylate

HRID 978090노트

반응식

HRID 978090 반응식
[OH:1][C:2]1[C:3]2[CH:14]=[CH:13][CH:12]=[CH:11][C:4]=2[S:5][C:6]=1[C:7]([O:9][CH3:10])=[O:8].[N+](=[CH2:17])=[N-]>C(Cl)Cl>[CH3:17][O:1][C:2]1[C:3]2[CH:14]=[CH:13][CH:12]=[CH:11][C:4]=2[S:5][C:6]=1[C:7]([O:9][CH3:10])=[O:8]

참가 물질

4

반응물 2

HCID 9550Diazomethane2회HCID 83165Methyl 3-hydroxybenzo[b]thiophene-3-carboxylate

생성물 1

HCID 88021Methyl 3-methoxy-1-benzothiophene-2-carboxylate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A stirred, ice-bath cooled mixture of methyl 3-hydroxybenzo[b]thiophene-2-carboxylate (J. Org. Chem. 32, 2678 (1967) (2.1 g, 0.01 m) and dry methylene chloride (25 ml) was treated with ethereal diazomethane in portions until the yellow color of the diazomethane persists, and nitrogen was no longer evolved. Concentration in vacuo yielded methyl 3-methoxybenzo[b]-thiophene-2-carboxylate as a pale tan solid; m/z 324 (M+.). The material was used without further purification in the next step.

후처리

  1. temperatureA stirred, ice-bath cooled
  2. concentrationConcentration in vacuo

출처 및 근거

ORD 기록
ord-944b2aedf42a417992288918ecffac7c
출처 데이터셋
uspto-grants-1987_05
특허 번호
US04663344

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