Sodium Hydroxide → E-3-(4-hydroxy-3-methylbenzofuran-2-yl)propenoic acid

HRID 978119노트

반응식

HRID 978119 반응식
[OH:1][C:2]1[C:7]2[C:8]([CH3:18])=[C:9](/[CH:11]=[CH:12]/[C:13]([O:15]CC)=[O:14])[O:10][C:6]=2[CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>CO>[OH:1][C:2]1[C:7]2[C:8]([CH3:18])=[C:9](/[CH:11]=[CH:12]/[C:13]([OH:15])=[O:14])[O:10][C:6]=2[CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 13849545Ethyl (E)-3-(4-hydroxy-3-methylbenzofuran-2-yl)propenoate

생성물 1

HCID 13849550E-3-(4-hydroxy-3-methylbenzofuran-2-yl)propenoic acid수율 96.7%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of ethyl-E-3-(4-hydroxy-3-methylbenzofuran-2-yl)propenoate (225 mg, 0.9 mmoles) (From Example 159), 2N sodium hydroxide (4 ml) and methanol (15 ml) was stirred at room temperature for 36 hours. The mixture was concentrated, acidified with 20% citric acid solution and extracted with ether. The ether solution was dried with Na2SO4, filtered and concentrated to obtain 190 mg of the title compound, m.p. 246°-248° C. (dec.).

후처리

  1. concentrationThe mixture was concentrated
  2. extractionextracted with ether
  3. dry with materialThe ether solution was dried with Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-5d4c08c195b64b72b2ba6a5bd5e0b2db
출처 데이터셋
uspto-grants-1987_05
특허 번호
US04663347

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