3,6-Bis[2-(diethylamino)ethoxy]-4,5-acridinedimethanol → 3,6-Bis[2-(diethylamino)ethoxy]-4,5-diformylacridine

HRID 979106노트

반응식

HRID 979106 반응식
[CH2:1]([N:3]([CH2:33][CH3:34])[CH2:4][CH2:5][O:6][C:7]1[CH:8]=[CH:9][C:10]2[C:19]([C:20]=1[CH2:21][OH:22])=[N:18][C:17]1[C:16]([CH2:23][OH:24])=[C:15]([O:25][CH2:26][CH2:27][N:28]([CH2:31][CH3:32])[CH2:29][CH3:30])[CH:14]=[CH:13][C:12]=1[CH:11]=2)[CH3:2]>CS(C)=O.C(N(CC)CC)C>[CH2:31]([N:28]([CH2:29][CH3:30])[CH2:27][CH2:26][O:25][C:15]1[CH:14]=[CH:13][C:12]2[C:17]([C:16]=1[CH:23]=[O:24])=[N:18][C:19]1[C:10](=[CH:9][CH:8]=[C:7]([O:6][CH2:5][CH2:4][N:3]([CH2:33][CH3:34])[CH2:1][CH3:2])[C:20]=1[CH:21]=[O:22])[CH:11]=2)[CH3:32]

참가 물질

4

반응물 1

HCID 201846723,6-Bis[2-(diethylamino)ethoxy]-4,5-acridinedimethanol

생성물 1

HCID 202016653,6-Bis[2-(diethylamino)ethoxy]-4,5-diformylacridine수율 75.3%

시약·촉매·용매 2

HCID 679Dimethyl Sulfoxide용매2회HCID 8471Triethylamine용매

실험 절차

To a solution of 0.469 g of 3,6-bis[2-(diethylamino)ethoxy]-4,5-acridinedimethanol in a mixture of 5.0 ml of anhydrous dimethyl sulfoxide and 2.8 ml of triethylamine is added a solution of 0.96 g of sulfur trioxide-pyridine complex in 5 ml of anhydrous dimethyl sulfoxide. The reaction mixture is stirred at room temperature for one hour. Most of the dimethyl sulfoxide is removed under reduced pressure without heat. The residue is treated first with 50 ml of saturated sodium bicarbonate solution and then with 50 ml of water, giving 0.35 g of the desired product as a yellow solid.

후처리

  1. customMost of the dimethyl sulfoxide is removed under reduced pressure
  2. temperaturewithout heat
  3. additionThe residue is treated first with 50 ml of saturated sodium bicarbonate solution

출처 및 근거

ORD 기록
ord-8f0c4ed1ce7f48d0914e1345f46eaadc
출처 데이터셋
uspto-grants-1987_05
특허 번호
US04666917

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