Water → chloromaleic acid N-[2-(2-methoxyphenyl)-ethyl]-imide

HRID 979228

반응식

HRID 979228 반응식
[Cl:1][C:2]1[C:3]([O:5][C:6](=[O:8])[CH:7]=1)=[O:4].[CH3:9][O:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[CH2:17][CH2:18][NH2:19].O>C(O)(=O)C>[CH3:9][O:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[CH2:17][CH2:18][N:19]=[C:3]([OH:4])/[C:2](/[Cl:1])=[CH:7]\[C:6]([OH:5])=[O:8]

참가 물질

5

반응물 3

HCID 962WaterHCID 66772Chloromaleic anhydrideHCID 748962-Methoxyphenethylamine

생성물 1

HCID 178489456chloromaleic acid N-[2-(2-methoxyphenyl)-ethyl]-imide수율 78%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

13.25 g (0.1 mol) of chloromaleic anhydride and 15.2 g (0.1 mol) of 2-(2-methoxyphenyl)-ethylamine are heated to the boiling point in 100 ml of glacial acetic acid for 4 hours. 100 ml of water are then added and the oil which has precipitated is extracted with methylene chloride. The methylene chloride phase is separated off, washed with water, dried and evaporated. The oil which remains crystallizes. 20.8 g (78% of theory) of chloromaleic acid N-[2-(2-methoxyphenyl)-ethyl]-imide are obtained.

후처리

  1. customthe oil which has precipitated
  2. extractionis extracted with methylene chloride
  3. customThe methylene chloride phase is separated off
  4. washwashed with water
  5. customdried
  6. customevaporated
  7. customThe oil which remains crystallizes

출처 및 근거

ORD 기록
ord-33887f723c6e4b00a2adcfa2a364aa5b
출처 데이터셋
uspto-grants-1987_05
특허 번호
US04666935

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