Hydrazinecarboxylic acid, ethyl ester → Ethyl-3-(1-methyl-2-oxo(2H)quinoxalin-3-yl)carbazate

HRID 979464

반응식

HRID 979464 반응식
Cl[C:2]1[C:3](=[O:13])[N:4]([CH3:12])[C:5]2[C:10]([N:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.[C:14]([O:18][CH2:19][CH3:20])(=[O:17])[NH:15][NH2:16]>C(#N)C>[CH2:19]([O:18][C:14](=[O:17])[NH:15][NH:16][C:2]1[C:3](=[O:13])[N:4]([CH3:12])[C:5]2[C:10]([N:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH3:20]

참가 물질

4

반응물 2

HCID 20064Hydrazinecarboxylic acid, ethyl esterHCID 14710883-Chloro-1-methyl-1,2-dihydroquinoxalin-2-one

생성물 1

HCID 13192930Ethyl-3-(1-methyl-2-oxo(2H)quinoxalin-3-yl)carbazate

시약·촉매·용매 1

HCID 6342Acetonitrile용매

반응 조건

온도
9 °C

실험 절차

A solution of 152 g. (0.78 m.) of 3-chloro-1-methyl-1H-quinoxalin-2-one, 116 g. (1.1 m.) of ethyl carbazate and 1 l. of acetonitrile is refluxed for 16 hours. The mixture is cooled to 9° C. and the product collected by filtration and used directly for cyclization.

후처리

  1. filtrationthe product collected by filtration

출처 및 근거

ORD 기록
ord-342ba776234f489eadfc59b274f77f84
출처 데이터셋
uspto-grants-1987_05
특허 번호
US04668678

연결된 노트

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