Ammonia → 2-{Bicyclo[2.2.1]heptan-2-yl}ethan-1-amine

HRID 979792

반응식

[CH:1]12[CH2:7][CH:4]([CH2:5][CH2:6]1)[CH2:3][CH:2]2[CH2:8][C:9](O)=O.O=S(Cl)Cl.[NH3:16].[H-].[H-].[H-].[H-].[Li+].[Al+3]>>[CH:1]12[CH2:7][CH:4]([CH2:5][CH2:6]1)[CH2:3][CH:2]2[CH2:8][CH2:9][NH2:16]

참가 물질

반응물 4

HCID 222Ammonia

HCID 24386Thionyl Chloride

HCID 79139Norborn-2-ylacetic acid

HCID 21226445Aluminium lithium hydride

생성물 1

HCID 202228702-{Bicyclo[2.2.1]heptan-2-yl}ethan-1-amine수율 35%

실험 절차

Norbornane-2-acetic acid was treated with SOCl2, then with NH3. The resulting amine was reduced with LiAlH4 to give the desired intermediate. Yield: 35%.

출처 및 근거

ORD 기록: ord-89ff04e69db24ab5aa91db85b2fdded3
출처 데이터셋: uspto-grants-1987_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04634701

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