Sodium Hydroxide → 4-Ethoxy-3,5-dimethyl-2-pyridylmethanol

HRID 979862노트

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HRID 979862 반응식
C([O:4][CH2:5][C:6]1[C:11]([CH3:12])=[C:10]([O:13][CH2:14][CH3:15])[C:9]([CH3:16])=[CH:8][N:7]=1)(=O)C.[OH-].[Na+]>C(O)C>[CH2:14]([O:13][C:10]1[C:9]([CH3:16])=[CH:8][N:7]=[C:6]([CH2:5][OH:4])[C:11]=1[CH3:12])[CH3:15]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 22151469(4-Ethoxy-3,5-dimethyl-2-pyridyl)methyl acetate

생성물 1

HCID 199637424-Ethoxy-3,5-dimethyl-2-pyridylmethanol

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

32.9 g of (4-ethoxy-3,5-dimethyl-2-pyridyl)methyl acetate were dissolved in 190 ml of ethanol. 95 ml of 3N sodium hydroxide solution were then added dropwise thereto at 0° and the mixture was stirred at room temperature for a further 3 hours. The ethanol was subsequently removed in vacuo and the residual aqueous solution was extracted three times with 200 ml of methylene chloride. The organic extracts were dried over sodium sulfate and evaporated in vacuo. The residue crystallized from petroleum ether and there was obtained 4-ethoxy-3,5-dimethyl-2-pyridylmethanol of melting point 58°-59°.

후처리

  1. customThe ethanol was subsequently removed in vacuo
  2. extractionthe residual aqueous solution was extracted three times with 200 ml of methylene chloride
  3. dry with materialThe organic extracts were dried over sodium sulfate
  4. customevaporated in vacuo
  5. customThe residue crystallized from petroleum ether

출처 및 근거

ORD 기록
ord-56996fc754c547429746aec39ca9f110
출처 데이터셋
uspto-grants-1987_01
특허 번호
US04634710

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