Potassium cyanate → N-[4-[2-(1H-Imidazol-1-yl)ethoxy]phenyl]urea

HRID 980148노트

반응식

HRID 980148 반응식
[NH2:1][C:2]1[CH:15]=[CH:14][C:5]([O:6][CH2:7][CH2:8][N:9]2[CH:13]=[CH:12][N:11]=[CH:10]2)=[CH:4][CH:3]=1.[O-:16][C:17]#[N:18].[K+]>Cl.O>[NH:1]([C:2]1[CH:3]=[CH:4][C:5]([O:6][CH2:7][CH2:8][N:9]2[CH:13]=[CH:12][N:11]=[CH:10]2)=[CH:14][CH:15]=1)[C:17]([NH2:18])=[O:16]

참가 물질

5

반응물 2

HCID 11378442Potassium cyanateHCID 135692034-[2-(1H-Imidazol-1-yl)ethoxy]aniline

생성물 1

HCID 13569204N-[4-[2-(1H-Imidazol-1-yl)ethoxy]phenyl]urea수율 82.5%

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 962Water용매

실험 절차

1-[2-(4-Aminophenoxy)ethyl]imidazole (0.6 g) was dissolved in 1N hydrochloric acid (3.0 ml) and a solution of potassium cyanate (0.3 g) in 1 ml of water was added. The mixture was allowed to stand at room temperature for 15 minutes and the resulting solid was filtered off, washed with water and crystallised from water to give 1-[2-(4-ureidophenoxy)ethyl]imidazole (0.6 g), m.p. 199°-201° C. Found: C, 58.20; H, 5.70; N, 23.06. C12H14N4O2 requires: C, 58.52; H, 5.73; N, 22.75%.

후처리

  1. filtrationthe resulting solid was filtered off
  2. washwashed with water
  3. customcrystallised from water

출처 및 근거

ORD 기록
ord-bb0891538fbb440d862e6ab28e6776b4
출처 데이터셋
uspto-grants-1987_01
특허 번호
US04636500

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