2,4-Dichlorobenzaldehyde → HCID 2872053, 화합물

HRID 980844노트

반응식

HRID 980844 반응식
[Cl:1][C:2]1[CH:9]=[C:8]([Cl:10])[CH:7]=[CH:6][C:3]=1[CH:4]=O.[C:11](O)(=[S:15])[CH:12](C)O.[CH:17]([O-:19])=O.[NH4+:20]>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:9]=[C:8]([Cl:10])[CH:7]=[CH:6][C:3]=1[CH:4]1[NH:20][C:17](=[O:19])[CH:11]([CH3:12])[S:15]1

참가 물질

5

반응물 3

HCID 134042,4-DichlorobenzaldehydeHCID 2723923Ammonium formateHCID 178473673HCID 178473673, 화합물

생성물 1

HCID 2872053HCID 2872053, 화합물수율 85.3%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

In a 500 ml 3-necked flask equipped with a Dean & Stark trap and reflux condenser, 30 g (0.17 mole) 2,4-dichlorobenzaldehyde, 18.2 g (0.17 mole) 95% thiolactic acid and 10.8 g (0.17 mole) ammonium formate in 150 ml toluene were placed. The reaction mixture was heated to reflux for several hours; 17 ml water collected. The mixture was at first clear in color and then turned yellow. The reaction mixture was allowed to sit overnight during which yellow solids precipitated. The mixture was filtered. The solids were washed with ether and then air dried to give 38 g of the above-identified product as a white solid.

후처리

  1. customIn a 500 ml 3-necked flask equipped with a Dean & Stark trap
  2. temperaturereflux condenser
  3. temperatureThe reaction mixture was heated
  4. temperatureto reflux for several hours
  5. custom17 ml water collected
  6. customprecipitated
  7. filtrationThe mixture was filtered
  8. washThe solids were washed with ether
  9. customair dried

출처 및 근거

ORD 기록
ord-4a90b5d585b84a69abc30eb38845b60c
출처 데이터셋
uspto-grants-1987_01
특허 번호
US04639460

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