Sodium Hydroxide → 6-Benzyl-octahydropyrrolo[3,4-b][1,4]oxazine

HRID 981078노트

반응식

HRID 981078 반응식
[CH2:1]([N:8]1[CH2:12][CH:11](O)[CH:10]([NH:14][CH2:15][CH2:16][OH:17])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>S(=O)(=O)(O)O.O>[CH2:1]([N:8]1[CH2:12][CH:11]2[CH:10]([NH:14][CH2:15][CH2:16][O:17]2)[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 19969797HCID 19969797, 화합물

생성물 1

HCID 150699806-Benzyl-octahydropyrrolo[3,4-b][1,4]oxazine

시약·촉매·용매 2

HCID 962Water용매HCID 1118Sulfuric Acid용매

실험 절차

15.6 g (66 mmol) of 1-benzyl-4-hydroxy-3-(2-hydroxyethylamino)-pyrrolidine are heated under reflux in a mixture of 60 ml of concentrated sulphuric acid and 20 ml of water for 6 hours. The mixture is rendered alkaline with concentrated sodium hydroxide solution, the sodium sulphate which has precipitated is filtered off with suction and the filtrate is extracted with chloroform. The extract is dried over potassium carbonate and concentrated and the residue is distilled.

후처리

  1. customthe sodium sulphate which has precipitated
  2. filtrationis filtered off with suction
  3. extractionthe filtrate is extracted with chloroform
  4. dry with materialThe extract is dried over potassium carbonate
  5. concentrationconcentrated
  6. distillationthe residue is distilled

출처 및 근거

ORD 기록
ord-a007d9236d604f5cb12d7357eaab8609
출처 데이터셋
uspto-grants-1991_02
특허 번호
US04990517

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