2-Chloroethanol → 2-(4-Iodophenoxy)ethanol

HRID 981145

반응식

HRID 981145 반응식
[Na].[I:2][C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[CH:5][CH:4]=1.Cl[CH2:11][CH2:12][OH:13].[Cl-].[NH4+]>C(O)C>[I:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH2:11][CH2:12][OH:13])=[CH:5][CH:4]=1

참가 물질

6

반응물 4

HCID 342-ChloroethanolHCID 108944-IodophenolHCID 25517Ammonium ChlorideHCID 5360545Sodium

생성물 1

HCID 35132082-(4-Iodophenoxy)ethanol수율 50%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Sodium (0.53 g) was dissolved in ethanol (50 ml) under nitrogen and 4-iodophenol (5.0 g), and 2-chloroethanol (3.93 g), were added successively. The mixture was refluxed for 18 h, treated with saturated aqueous ammonium chloride (50 ml) and evaporated. The aqueous residue was extracted with ER (3×100 ml) and the dried extract was evaporated onto silica (Merck 9385; 50 ml) and purified by [C] eluted with cyclohexane-ER (7:3) followed by cyclohexane-ER (1:1) to give the title compound (3.0 g) m.p. 76°-77°.

후처리

  1. temperatureThe mixture was refluxed for 18 h
  2. customevaporated
  3. extractionThe aqueous residue was extracted with ER (3×100 ml)
  4. extractionthe dried extract
  5. customwas evaporated onto silica (Merck 9385; 50 ml)
  6. custompurified by [C]
  7. washeluted with cyclohexane-ER (7:3)

출처 및 근거

ORD 기록
ord-bb88b4021fb443c68845c639338c7086
출처 데이터셋
uspto-grants-1991_02
특허 번호
US04990505

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