Water → 2-(2-Propylimidazol-1-yl)propan-1-ol

HRID 981524노트

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HRID 981524 반응식
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH2:7]([C:10]1[N:11]([CH:15]([CH3:21])[C:16](OCC)=[O:17])[CH:12]=[CH:13][N:14]=1)[CH2:8][CH3:9].O.[OH-].[Na+]>O1CCCC1>[CH2:7]([C:10]1[N:11]([CH:15]([CH3:21])[CH2:16][OH:17])[CH:12]=[CH:13][N:14]=1)[CH2:8][CH3:9]

참가 물질

6

반응물 4

HCID 962Water2회HCID 14798Sodium HydroxideHCID 20070368Ethyl-2-(2-propylimidazol-1-yl)propanoateHCID 21226445Aluminium lithium hydride

생성물 1

HCID 200703742-(2-Propylimidazol-1-yl)propan-1-ol수율 73.4%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

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온도
0 °C

실험 절차

Lithium aluminum hydride (2.5 g) was suspended in tetrahydrofuran (40 ml). Ethyl 2-(2-propylimidazol-1-yl)propanate [9.2 g] in tetrahydrofuran (40 ml) was added with stirring at 0° C. The reaction was refluxed for 3 hours, cooled to 0° C., water (3 ml) was added dropwise followed by 15% sodium hydroxide (3 ml) and a further portion of water (9 ml). The suspension was filtered through solka-flok and the solvent removed under reduced pressure. Dichloromethane (50 ml) was added, the organic phase washed with brine (25 ml) dried over magnesium sulphate and the solvent removed under reduced pressure yielding the title compound as a white foam 5.4 g (67%).

후처리

  1. temperatureThe reaction was refluxed for 3 hours
  2. temperaturecooled to 0° C.
  3. filtrationThe suspension was filtered through solka-flok and the solvent
  4. customremoved under reduced pressure
  5. additionDichloromethane (50 ml) was added
  6. washthe organic phase washed with brine (25 ml)
  7. dry with materialdried over magnesium sulphate
  8. customthe solvent removed under reduced pressure

출처 및 근거

ORD 기록
ord-69b82512971c44f685a7bca09bba6dcf
출처 데이터셋
uspto-grants-1991_02
특허 번호
US04992447

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