Thionyl Chloride → Ethyl 4-(3-chloro-3-oxopropyl)-1-piperidinecarboxylate
반응식
[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][CH:9]([CH2:12][CH2:13][C:14]([OH:16])=O)[CH2:8][CH2:7]1)=[O:5])[CH3:2].S(Cl)([Cl:19])=O>ClC(Cl)Cl>[Cl:19][C:14](=[O:16])[CH2:13][CH2:12][CH:9]1[CH2:10][CH2:11][N:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH2:7][CH2:8]1참가 물질
4
실험 절차
To a stirred mixture of 200 parts of 1-(ethoxycarbonyl)-4-piperidinepropanoic acid and 750 parts of trichloromethane were added 320 parts of thionyl chloride. The whole was stirred for 18 hours at room temperature. The reaction mixture was evaporated with methylbenzene. The residue was distilled, yielding 102.6 parts (47%) of ethyl 4-(3-chloro-3-oxopropyl)-1-piperidinecarboxylate; bp. 165-170 at 399 Pa (int. 45).
후처리
- customThe reaction mixture was evaporated with methylbenzene
- distillationThe residue was distilled
출처 및 근거
- ORD 기록
- ord-4ef05e2268014532bda894b397d622e2
- 출처 데이터셋
- uspto-grants-1991_02
- 특허 번호
- US04992433
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