Ammonia → N1-[3-(Trifluoromethyl)phenyl]-1,3-propanediamine
반응식
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:4]=[C:5]([NH:9][CH2:10][CH2:11][C:12]#[N:13])[CH:6]=[CH:7][CH:8]=1.N.[H][H]>[Ni].CO>[F:1][C:2]([F:14])([F:15])[C:3]1[CH:4]=[C:5]([NH:9][CH2:10][CH2:11][CH2:12][NH2:13])[CH:6]=[CH:7][CH:8]=1참가 물질
6
실험 절차
A mixture of 13.6 parts of 3-[[3-(trifluoromethyl)phenyl]amino]propanenitrile and 400 parts of methanol saturated with ammonia was hydrogenated at normal pressure and at a temperature below 20° C. with 3 parts of Raney Nickel catalyst. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated, yielding 13 parts (100%) of N1 -[3-(trifluoromethyl)phenyl]-1,3-propanediamine as a residue (int. 106).
후처리
- filtrationthe catalyst was filtered off
- customthe filtrate was evaporated
출처 및 근거
- ORD 기록
- ord-ab14dc60e28b4dc8b4fba4c874ade40a
- 출처 데이터셋
- uspto-grants-1991_02
- 특허 번호
- US04992433
반응 노트
불러오는 중…