4-Nitrophenol → 6-nitro-3,4-dihydro-2H-1-benzopyran-4-one

HRID 981786

반응식

HRID 981786 반응식
[CH:1]1[C:6]([N+:7]([O-:9])=[O:8])=[CH:5][CH:4]=[C:3]([OH:10])[CH:2]=1.[C:11](O)(=[O:14])[CH:12]=[CH2:13].C1C2NC3C(=CC=CC=3)SC=2C=CC=1.F>>[N+:7]([C:6]1[CH:5]=[C:4]2[C:3](=[CH:2][CH:1]=1)[O:10][CH2:13][CH2:12][C:11]2=[O:14])([O-:9])=[O:8]

참가 물질

5

반응물 4

HCID 9804-NitrophenolHCID 6581Acrylic AcidHCID 7108PhenothiazineHCID 14917Hydrofluoric Acid

생성물 1

HCID 52288316-nitro-3,4-dihydro-2H-1-benzopyran-4-one

실험 절차

Following the same procedure as Example 1, p-nitrophenol (34.8 grams), acrylic acid (27 grams), and an inhibitor, phenothiazine (0.02 grams) was added to the pressure reactor. The anhydrous hydrogen fluoride (110 grams) was added before the system was warmed. When the reaction temperature was attained, a pressure of 140 psig was noted, similar to previous reactions. Work-up was carried out as previous examples and the 6-Nitro-4-Chromanone was isolated and characterized.

후처리

  1. temperaturewas warmed

출처 및 근거

ORD 기록
ord-da5d1197fd644d779e21cbae81c0ff80
출처 데이터셋
uspto-grants-1991_02
특허 번호
US04992564

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