1,6-Dibromohexane → HCID 19876744, 화합물

HRID 982383노트

반응식

HRID 982383 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][OH:13].[Br:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]Br.[OH-].[Na+]>O.CCOCC>[Br:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][O:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][C:2]1[N:3]=[CH:4][CH:5]=[CH:6][N:1]=1

참가 물질

6

반응물 3

HCID 123681,6-DibromohexaneHCID 14798Sodium HydroxideHCID 198767736-(Pyrimidin-2-YL)hexan-1-OL

생성물 1

HCID 19876744HCID 19876744, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 3283Diethyl Ether용매

실험 절차

A mixture of 2-pyrimidinehexanol (1.18 g), 1,6-dibromohexane (4 ml), 50% sodium hydroxide (4 ml) and TAB (100 mg) was vigorously stirred at room temperature for 17 h, then diluted with water (40 ml) and ether (50 ml). The organic phase was dried and evaporated in vacuo to an oil which was purified by FCC. Elution with hexane followed by hexane-ether (1:1) gave the title compound as a colourless oil (670 mg), t.l.c. (ether) Rf 0.24

후처리

  1. customThe organic phase was dried
  2. customevaporated in vacuo to an oil which
  3. customwas purified by FCC
  4. washElution with hexane

출처 및 근거

ORD 기록
ord-cebf3741cb2a4691ac23c178a8be2009
출처 데이터셋
uspto-grants-1991_02
특허 번호
US04996218

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