1,6-Dibromohexane → 5-[6-[(6-Bromohexyl)oxy]hexyl]pyrimidine

HRID 982384노트

반응식

HRID 982384 반응식
[N:1]1[CH:6]=[C:5]([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][OH:13])[CH:4]=[N:3][CH:2]=1.[OH-].[Na+].[Br:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22]Br>O.CCOCC>[Br:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][O:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][C:5]1[CH:6]=[N:1][CH:2]=[N:3][CH:4]=1

참가 물질

6

반응물 3

HCID 123681,6-DibromohexaneHCID 14798Sodium HydroxideHCID 135575446-(Pyrimidin-5-yl)hexan-1-ol

생성물 1

HCID 198767545-[6-[(6-Bromohexyl)oxy]hexyl]pyrimidine

시약·촉매·용매 2

HCID 962Water용매HCID 3283Diethyl Ether용매

실험 절차

A mixture of 5-pyrimidinehexanol (1.82 g), 50% sodium hydroxide (6 ml), 1,6-dibromohexane (6 ml) and TAB (150 mg) was vigorously stirred at room temperature for 30 h then diluted with water (20 ml) and ether (25 ml). The organic phase was dried and evaporated in vacuo. The residue was purified by FCC eluting with hexane followed by hexane-ether (1:1) and ether, to give the title compound as a colourless liquid (2.21 g), t.l.c. (ether) Rf 0.35.

후처리

  1. customThe organic phase was dried
  2. customevaporated in vacuo
  3. customThe residue was purified by FCC
  4. washeluting with hexane

출처 및 근거

ORD 기록
ord-385cdbf4a8c340ed90403123ae3429cc
출처 데이터셋
uspto-grants-1991_02
특허 번호
US04996218

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