1,1-Dibromoethane → 1,2-Diphenyl-1-[4-(2-bromoethoxy)phenyl]-1-buten-4-ol

HRID 982442노트

반응식

HRID 982442 반응식
[C:1]1(/[C:7](/[C:18]2[CH:23]=[CH:22][C:21]([OH:24])=[CH:20][CH:19]=2)=[C:8](/[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)\[CH2:9][CH2:10][OH:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:25][CH:26](Br)[CH3:27].C(=O)([O-])[O-].[K+].[K+]>C(C(C)=O)C>[C:1]1([C:7]([C:18]2[CH:19]=[CH:20][C:21]([O:24][CH2:27][CH2:26][Br:25])=[CH:22][CH:23]=2)=[C:8]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:9][CH2:10][OH:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 3

HCID 112011,1-DibromoethaneHCID 11430Potassium CarbonateHCID 13298065Z-4-(4-hydroxy-1,2-diphenyl-but-1-enyl)-phenol

생성물 1

HCID 544646161,2-Diphenyl-1-[4-(2-bromoethoxy)phenyl]-1-buten-4-ol

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone용매

실험 절차

A mixture containing 31.6 g of (Z)-1,2-diphenyl-1-(4-hydroxyphenyl)-1-buten-4-ol, 93.9 g of dibromoethane, 20.7 g of anhydrous potassium carbonate and 250 ml of methyl ethyl ketone is refluxed for 24 h. The inorganic salts are removed by filtration followed by evaporating the solvent and recrystallizing from methanol. The yield is 17.3 g (41%) and m.p. 133°-7° C.

후처리

  1. temperatureis refluxed for 24 h
  2. customThe inorganic salts are removed by filtration
  3. customby evaporating the solvent
  4. customrecrystallizing from methanol

출처 및 근거

ORD 기록
ord-779fa5d296e14f008aece5d991d133c1
출처 데이터셋
uspto-grants-1991_02
특허 번호
US04996225

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