Hydrochloric Acid → 2,3,4,5-Tetrahydro-3-oxo-4-[(pyridin-3-yl)-methyleneamino]-6-methyl-1,2,4-triazinehydrochloride

반응식

[O:1]=[C:2]1[N:7]([N:8]=[CH:9][C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)[CH2:6][C:5]([CH3:16])=[N:4][NH:3]1.[ClH:17]>>[ClH:17].[O:1]=[C:2]1[N:7]([N:8]=[CH:9][C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)[CH2:6][C:5]([CH3:16])=[N:4][NH:3]1

참가 물질

반응물 2

HCID 313Hydrochloric Acid

HCID 863704,5-Dihydro-6-methyl-4-((3-pyridinylmethylene)amino)-1,2,4-triazin-3(2H)-one

생성물 1

HCID 679245022,3,4,5-Tetrahydro-3-oxo-4-[(pyridin-3-yl)-methyleneamino]-6-methyl-1,2,4-triazinehydrochloride

실험 절차

21.7 g of 2,3,4,5-tetrahydro-3-oxo-4-[(pyridin-3-yl)-methyleneamino]-6-methyl-1,2,4-triazine are dissolved, with heating, in 60 ml of 2N hydrochloride acid. The hot solution is filtered and cooled. The precipitate which crystallises out is isolated by filtration, washed with alcohol and ether and dried in vacuo to give the title compound of formula ##STR32## in the form of a colourless crystal powder; m.p. 240°-241° C. with decomposition; yield: 19 g (75 %).

후처리

filtrationThe hot solution is filtered
temperaturecooled
customThe precipitate which crystallises out
customis isolated by filtration
washwashed with alcohol and ether
customdried in vacuo

출처 및 근거

ORD 기록: ord-a367a6849efc4413b16a1055a1058d50
출처 데이터셋: uspto-grants-1991_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04996325

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