Hydrochloric Acid → Hydrochloric Acid

HRID 982606

반응식

HRID 982606 반응식
[NH:1](C(OCC1C=CC=CC=1)=O)[C@@H:2]([C:13]([NH2:15])=[O:14])[CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1.[ClH:26].O>CN(C=O)C.[Pd]>[ClH:26].[NH2:1][C@@H:2]([C:13]([NH2:15])=[O:14])[CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1

참가 물질

7

반응물 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 853881Z-D-Trp-NH2

생성물 2

HCID 313Hydrochloric AcidHCID 688582D-tryptophanamide

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 6228Dimethylformamide용매

실험 절차

Z-D-Trp-NH2 (3 g; 8.9 mmol; 1 eq.) was dissolved in DMF (100 ml). HCl 36% (845 μl; 1.1 eq.), water (2 ml) and palladium on activated charcoal (95 mg, 0.1 eq.) were added to the stirred mixture. The solution was bubbled under hydrogen for 24 hr. When the reaction went to completion, the palladium was filtered on celite. The solvent was removed in vacuo to afford HCl, H-D-Trp-NH2 as a colorless oil.

후처리

  1. customThe solution was bubbled under hydrogen for 24 hr
  2. filtrationthe palladium was filtered on celite
  3. customThe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-737ff3e68d314d74b8635aaef02a34a8
출처 데이터셋
uspto-grants-2005_03
특허 번호
US06861409B2

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