Hydrochloric Acid → 1-(3-Fluoro-4-methylphenyl)ethanol

HRID 982743

반응식

HRID 982743 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[CH3:10])[CH:5]=[O:6].[CH3:11][Mg]Br.Cl>C1COCC1>[OH:6][CH:5]([C:4]1[CH:7]=[CH:8][C:9]([CH3:10])=[C:2]([F:1])[CH:3]=1)[CH3:11]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 27745743-Fluoro-4-methylbenzaldehydeHCID 178418573HCID 178418573, 화합물

생성물 1

HCID 219913931-(3-Fluoro-4-methylphenyl)ethanol수율 100.5%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

To an ice-cold solution of 3-fluoro-4-methylbenzaldehyde (50 mg, 0.36 mmol) in THF (0.5 mL) was added dropwise a 0.93 M solution (0.47 mL) of methylmagnesium bromide (0.44 mmol) in THF. The temperature of the reaction mixture was allowed to rise back to room temperature, at which the reaction mixture was stirred for 1 hour. Then, 2 mol/L hydrochloric acid was added, and the mixture was extracted with ethyl acetate. The extract was washed with brine and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to yield title compound as a pale yellow oil (55.8 mg, quantitative).

후처리

  1. customto rise back to room temperature, at which
  2. extractionthe mixture was extracted with ethyl acetate
  3. washThe extract was washed with brine
  4. dry with materialdried over anhydrous sodium sulfate
  5. distillationThe solvent was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-e56ec66b227a4be99cd05080dffe8546
출처 데이터셋
uspto-grants-2005_03
특허 번호
US06861428B2

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