Lithium Hydroxide → HCID 178418698, 화합물
반응식
[CH3:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([OH:16])=[CH:7][C:8]([C:12]([O:14]C)=[O:13])=[N:9]2)=[CH:4][CH:3]=1.[Li+].[OH-]>CO.O>[CH3:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([OH:16])=[CH:7][C:8]([C:12]([OH:14])=[O:13])=[N:9]2)=[CH:4][CH:3]=1참가 물질
5
실험 절차
7-methyl-4-hydroxy-2-methoxycarbonylquinoline (6.45 g, 30.14 mmol) was suspended in MeOH (150 mL) and water (100 mL), and LiOH (3.08 g, 75.5 mmol) was added and stirred at ambient temperature for 2 hours. The methanol was evaporated in vacuo and residue was crystallized by addition of 2N hydrochloric acid. The resulting solid was filtered, washed with water and dried to afford 7-methyl-4-hydroxy-2-carboxyquinoline (6.0 g, 98%), NMR (DMSO-d6) 2.40 (s, 3), 6.68 (s, 1), 7.22 (d, 1), 7.68 (s, 1), 7.96 (d, 1).
후처리
- customThe methanol was evaporated in vacuo and residue
- customwas crystallized by addition of 2N hydrochloric acid
- filtrationThe resulting solid was filtered
- washwashed with water
- customdried
출처 및 근거
- ORD 기록
- ord-21e851375dbd4c21b9a06e7f729ffef3
- 출처 데이터셋
- uspto-grants-2005_03
- 특허 번호
- US06861424B2
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