Hydroxylamine HCl → 1,5,6,7-Tetrahydro-indol-4-one oxime

HRID 983056

반응식

HRID 983056 반응식
[NH:1]1[C:9]2[CH2:8][CH2:7][CH2:6][C:5](=O)[C:4]=2[CH:3]=[CH:2]1.[Cl-].[OH:12][NH3+:13]>N1C=CC=CC=1>[NH:1]1[C:9]2[CH2:8][CH2:7][CH2:6][C:5](=[N:13][OH:12])[C:4]=2[CH:3]=[CH:2]1

참가 물질

4

반응물 2

HCID 21645Hydroxylamine HClHCID 2802291,5,6,7-Tetrahydro-4H-indol-4-one

생성물 1

HCID 9156771,5,6,7-Tetrahydro-indol-4-one oxime

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To a stirred solution of 1,5,6,7-tetrahydro-indol-4-one (5.4 g) in pyridine (40 mL) was added hydroxyammonium chloride (2 eq.) at rt. After 2 hours, the solvent was removed and the residue was diluted with water and extracted with ethyl acetate. The combined extracts were washed with brine, dried and concentrated to give 5.5 g of 1,5,6,7-tetrahydro-indol-4-one oxime as a pale yellow solid.

후처리

  1. customthe solvent was removed
  2. additionthe residue was diluted with water
  3. extractionextracted with ethyl acetate
  4. washThe combined extracts were washed with brine
  5. customdried
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-67cf765a192c41c893670e580db22e07
출처 데이터셋
uspto-grants-2005_03
특허 번호
US06861418B2

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