1-(1-Benzylpyrrolidin-3-yl)ethan-1-one → HCID 22560190, 화합물

HRID 983396노트

반응식

HRID 983396 반응식
[C:1]([CH:4]1[CH2:8][CH2:7][N:6]([CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH2:5]1)(=[O:3])[CH3:2].[BH4-].[Na+]>CO>[CH2:9]([N:6]1[CH2:7][CH2:8][CH:4]([CH:1]([OH:3])[CH3:2])[CH2:5]1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

참가 물질

4

반응물 2

HCID 3579521-(1-Benzylpyrrolidin-3-yl)ethan-1-oneHCID 4311764Sodium borohydride

생성물 1

HCID 22560190HCID 22560190, 화합물수율 74.6%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a 5° C. solution of 3-acetyl-1-benzylpyrrolidine (1 g, 4.9 mmol [L. E. Overman, J. Am. Chem. Soc. 1983, 105, 6622]) in methanol (10 mL) was added portionwise sodium borohydride (0.37 g, 9.8 mmol). After stirring at room temperature for 17 hours, the mixture was concentrated, diluted with ethyl acetate, washed with water, brine, dried with sodium sulfate and concentrated to afford the title compound (0.75 g). MSCI: m/z=206 (MH+).

후처리

  1. concentrationthe mixture was concentrated
  2. additiondiluted with ethyl acetate
  3. washwashed with water, brine
  4. dry with materialdried with sodium sulfate
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-8484d10411fa4e2f8592a0971fe058fc
출처 데이터셋
uspto-grants-2005_03
특허 번호
US06864259B2

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