Benzyl Alcohol → 2-(Benzyloxy)benzyl-triphenylphosphonium bromide

HRID 983646

반응식

HRID 983646 반응식
[CH2:1]([OH:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[BrH:9].[C:10]1([PH+:16]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>C(#N)C>[Br-:9].[CH2:1]([O:8][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[CH2:1][P+:16]([C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1)([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 244Benzyl AlcoholHCID 22178555Triphenylphosphonium hydrobromide

생성물 1

HCID 114101092-(Benzyloxy)benzyl-triphenylphosphonium bromide

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

15.15 g (70.7 mmol) of the benzyl alcohol IIIa and 21.86 g (63.7 mmol) of triphenyl-phosphonium hydrobromide in 240 ml of acetonitrile are heated at reflux for 5 hours. The solvent is evaporated under reduced pressure, and diethyl ether is then added. The solid is filtered and dried under reduced pressure.

후처리

  1. temperatureat reflux for 5 hours
  2. customThe solvent is evaporated under reduced pressure, and diethyl ether
  3. additionis then added
  4. filtrationThe solid is filtered
  5. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-386711396fe54941b2746e6a44162c3f
출처 데이터셋
uspto-grants-2005_03
특허 번호
US06864287B1

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