Benzene → 3,5,5-Trimethylhexanoylbenzene

HRID 983741

반응식

HRID 983741 반응식
[Cl-].[Al+3].[Cl-].[Cl-].[CH3:5][CH:6]([CH2:11][C:12]([CH3:15])([CH3:14])[CH3:13])[CH2:7][C:8](Cl)=[O:9].[CH:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[CH3:5][CH:6]([CH2:11][C:12]([CH3:15])([CH3:14])[CH3:13])[CH2:7][C:8]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:9]

참가 물질

4

반응물 3

HCID 241BenzeneHCID 1619293,5,5-Trimethylhexanoyl chlorideHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 222694783,5,5-Trimethylhexanoylbenzene

실험 절차

To a mixture of 143.3 grams of aluminum chloride and 400 mL of benzene was added 100 grams of 3,5,5-trimethylhexanoyl chloride over a 50 minute period at a rate such that the temperature did not exceed 35° C. When the addition was complete, the mixture was stirred at room temperature for three hours. The mixture was poured over 500 grams of ice and extracted with 400 mL of ethyl acetate. The organic phase was washed with brine, dried over magnesium sulfate, filtered and the solvent was removed in vacuo to give 3,5,5-trimethylhexanoylbenzene.

후처리

  1. customdid not exceed 35° C
  2. additionWhen the addition
  3. extractionextracted with 400 mL of ethyl acetate
  4. washThe organic phase was washed with brine
  5. dry with materialdried over magnesium sulfate
  6. filtrationfiltered
  7. customthe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-7b4b6970e38e48e3a6b6c40f9c13e7c2
출처 데이터셋
uspto-grants-2005_03
특허 번호
US06864396B2

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