(1,1'-Biphenyl)-2-ol → 6-Phenylhexan-1-amine

HRID 984630노트

반응식

HRID 984630 반응식
P([O-])([O-])([O-])=O.[K+].[K+].[K+].[C:9]1([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2O)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.BrC1C=CC=CC=1.C([NH2:35])CCCCC.CCCCCCCCCCCC>[Cu]I.O.C(OCC)C.C1(C)C=CC=CC=1>[C:9]1([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][NH2:35])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

참가 물질

10

반응물 5

HCID 7017(1,1'-Biphenyl)-2-olHCID 7961BromobenzeneHCID 8102HexylamineHCID 8182DodecaneHCID 62657Potassium Phosphate, Tribasic

생성물 1

HCID 1455586-Phenylhexan-1-amine

시약·촉매·용매 4

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)촉매HCID 962Water용매HCID 1140Toluene용매HCID 3283Diethyl Ether용매

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온도
100 °C

실험 절차

Copper (I) iodide (10 mg, 0.05 mmol, 5 mol %), anhydrous fine powder potassium phosphate (425 mg, 2.0 mmol) and 2-phenylphenol (34 mg, 0.2 mmol, 20 mol %) were put into a screw-capped test tube with a Teflon septum. Anhydrous toluene (1.0 mL), bromobenzene (105 μL, 1.0 mmol) and n-hexylamine (158 μL, 1.2 mmol) were added by micro-syringe at room temperature under air atmosphere. The reaction mixture was heated at 100° C. for 22 hours. The reaction mixture was then allowed to reach room temperature. Diethyl ether (2 mL), water (2 mL) and dodecane (internal standard, 227 μL) were added. The organic layer was analyzed by GC to give 33% GC yield of N-phenylhexylamine.

후처리

  1. customto reach room temperature

출처 및 근거

ORD 기록
ord-5ceefe466195443c91d935e20ef7fdf3
출처 데이터셋
uspto-grants-2005_03
특허 번호
US06867298B2

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