2-(Methylthio)benzimidazole → 1-(4,6-Dimethoxypyrimidin-2-yl)-2-methylthiobenzimidazole

HRID 985446

반응식

HRID 985446 반응식
[CH3:1][S:2][C:3]1[NH:4][C:5]2[CH:11]=[CH:10][CH:9]=[CH:8][C:6]=2[N:7]=1.[H-].[Na+].CS([C:18]1[N:23]=[C:22]([O:24][CH3:25])[CH:21]=[C:20]([O:26][CH3:27])[N:19]=1)(=O)=O>CN(C)C=O>[CH3:27][O:26][C:20]1[CH:21]=[C:22]([O:24][CH3:25])[N:23]=[C:18]([N:7]2[C:6]3[CH:8]=[CH:9][CH:10]=[CH:11][C:5]=3[N:4]=[C:3]2[S:2][CH3:1])[N:19]=1

참가 물질

5

반응물 3

HCID 235392-(Methylthio)benzimidazoleHCID 24758Sodium hydrideHCID 8383634,6-Dimethoxy-2-(methylsulfonyl)pyrimidine

생성물 1

HCID 120569281-(4,6-Dimethoxypyrimidin-2-yl)-2-methylthiobenzimidazole수율 86.9%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

2-Methylthiobenzimidazole (0.50 g) was dissolved in dimethylformamide (10 ml), and sodium hydride (60% purity, oily) (0.13 g) was added thereto at room temperature. After stirring for 1 hour, 2-methylsulfonyl-4,6-dimethoxypyrimidine (0.67 g) was added at room temperature, followed by stirring for 8 hours. Ice water was added, followed by extraction with ethyl acetate, washing with a saturated sodium chloride aqueous solution and drying over anhydrous magnesium sulfate. The solvent was distilled off, and the residue was purified by silica gel column chromatography to obtain 0.80 g of the desired product as a white powder (m.p. 135-137° C.).

후처리

  1. customat room temperature
  2. stirringby stirring for 8 hours
  3. extractionfollowed by extraction with ethyl acetate
  4. washwashing with a saturated sodium chloride aqueous solution
  5. dry with materialdrying over anhydrous magnesium sulfate
  6. distillationThe solvent was distilled off
  7. customthe residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-37bb7a63f4864f6d82b49b13368259a3
출처 데이터셋
uspto-grants-2005_03
특허 번호
US06872729B2

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