Sodium Dithionite → HCID 22506839, 화합물

HRID 985572노트

반응식

HRID 985572 반응식
[CH3:1][C:2]1([CH3:14])[CH2:10][C:9]2[C:4]([C:5]([CH3:13])=[CH:6][C:7](=[O:12])[C:8]=2[CH3:11])=[N:3]1.S(S([O-])=O)([O-])=O.[Na+].[Na+]>C(OCC)(=O)C.O>[CH3:1][C:2]1([CH3:14])[CH2:10][C:9]2[C:4](=[C:5]([CH3:13])[CH:6]=[C:7]([OH:12])[C:8]=2[CH3:11])[NH:3]1

참가 물질

5

반응물 2

HCID 24489Sodium DithioniteHCID 22506843HCID 22506843, 화합물

생성물 1

HCID 22506839HCID 22506839, 화합물수율 83%

시약·촉매·용매 2

HCID 962Water용매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 2,3-dihydro-2,2,4,7-tetramethyl-5H-indol-5-one (7.36 g, 38.9 mmol) in ethyl acetate (100 ml) was added a solution of sodium hydrosulfite (14.9 g, 85.6 mmol) in water (50 ml) and shaken. The aqueous layer was separated, and the organic layer was washed with water and saturated brine, dried over magnesium sulfate, filtered and concentrated under reduced pressure. The residue was recrystallized from ethanol-hexane to obtain 6.17 g of the title compound.

후처리

  1. customThe aqueous layer was separated
  2. washthe organic layer was washed with water and saturated brine
  3. dry with materialdried over magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure
  6. customThe residue was recrystallized from ethanol-hexane

출처 및 근거

ORD 기록
ord-a3b42db1da98424989d852b792cf547c
출처 데이터셋
uspto-grants-2005_03
특허 번호
US06872718B1

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