Methyl 4-chloroacetoacetate → Methyl (R)-4-Chloro-3-hydroxybutyrate

HRID 985931노트

반응식

HRID 985931 반응식
[CH3:1][O:2][C:3](=[O:9])[CH2:4][C:5]([CH2:7][Cl:8])=[O:6]>C(Cl)(Cl)Cl>[CH3:1][O:2][C:3](=[O:9])[CH2:4][C@@H:5]([OH:6])[CH2:7][Cl:8]

참가 물질

3

반응물 1

HCID 36240Methyl 4-chloroacetoacetate

생성물 1

HCID 10920707Methyl (R)-4-Chloro-3-hydroxybutyrate

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

The procedure of example 369 was repeated using methyl-4-chloroacetoacetate as the substrate to afford methyl-4-chloro-3(R)-hydroxybutyrate, [α]D23 +21.15° (c, 4.2 CHCl3).

출처 및 근거

ORD 기록
ord-55b24647788e4d009f10f39b02477b2a
출처 데이터셋
uspto-grants-1987_12
특허 번호
US04710468

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