Imidazole → 1-(5-Nitro-2-methyl-phenylsulfonyl)-imidazole

HRID 985957

반응식

HRID 985957 반응식
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([CH3:14])=[C:8]([S:10](Cl)(=[O:12])=[O:11])[CH:9]=1)([O-:3])=[O:2].[NH:15]1[CH:19]=[CH:18][N:17]=[CH:16]1.O>N1C=CC=CC=1>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([CH3:14])=[C:8]([S:10]([N:15]2[CH:19]=[CH:18][N:17]=[CH:16]2)(=[O:12])=[O:11])[CH:9]=1)([O-:3])=[O:2]

참가 물질

5

반응물 3

HCID 795ImidazoleHCID 962WaterHCID 8457o-Toluenesulfonyl chloride, 5-nitro-

생성물 1

HCID 6850571-(5-Nitro-2-methyl-phenylsulfonyl)-imidazole수율 63.6%

시약·촉매·용매 1

HCID 1049Pyridine용매

반응 조건

온도
50 °C

실험 절차

2.36 g of 5-nitro-2-methyl-phenylsulfonyl chloride (0.01 mol) and 1.36 g of imidazole (0.02 mol) were dissolved in 15 ml of pyridine, and the mixture was stirred at 50° C. for 3 hours to react. After the reaction, the reaction mixture was poured into water, and extracted with chloroform. The chloroform layer was washed with water and dehydrated. Evaporation of chloroform gave 1.70 g of 1-(5-nitro-2-methyl-phenylsulfonyl)-imidazole of the m.p. 119°-120° C.

후처리

  1. customto react
  2. customAfter the reaction
  3. extractionextracted with chloroform
  4. washThe chloroform layer was washed with water
  5. customEvaporation of chloroform

출처 및 근거

ORD 기록
ord-fcb44b4c21584b2e92d076268a6bba5c
출처 데이터셋
uspto-grants-1987_12
특허 번호
US04710509

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