Hydrochloric Acid → (2RS, 3S)-3-amino-4-cyclohexyl-2-hydroxy-N-isobutylbutyramide hydrochloride
반응식
C(OC([NH:8][C@@H:9]([CH2:19][CH:20]1[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1)[CH:10]([OH:18])[C:11]([NH:13][CH2:14][CH:15]([CH3:17])[CH3:16])=[O:12])=O)(C)(C)C.[ClH:26]>CO>[ClH:26].[NH2:8][C@@H:9]([CH2:19][CH:20]1[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25]1)[CH:10]([OH:18])[C:11]([NH:13][CH2:14][CH:15]([CH3:16])[CH3:17])=[O:12]참가 물질
4
실험 절차
To a solution of 590 mg of the amide compound in 10 ml of methyl alcohol was added 3.3 ml of a 2N-hydrochloric acid, and the mixture was heated under reflux for 2 hours. The reaction mixture was evaporated under reduced pressure to obtain 254 mg of (2RS, 3S)-3-amino-4-cyclohexyl-2-hydroxy-N-isobutylbutyramide hydrochloride as a white powder.