Water → HCID 14032941, 화합물

HRID 986387노트

반응식

HRID 986387 반응식
[CH3:1][C:2]1[N:3]=[C:4]2[CH:9]=[CH:8][C:7]([CH3:10])=[CH:6][N:5]2[C:11]=1[C:12]([NH:14][NH2:15])=[O:13].C(N(CC)CC)C.[Cl:23][CH2:24][C:25](Cl)=[O:26].O>C(Cl)(Cl)Cl>[Cl:23][CH2:24][C:25]([NH:15][NH:14][C:12]([C:11]1[N:5]2[CH:6]=[C:7]([CH3:10])[CH:8]=[CH:9][C:4]2=[N:3][C:2]=1[CH3:1])=[O:13])=[O:26]

참가 물질

6

반응물 4

HCID 962WaterHCID 6577Chloroacetyl chlorideHCID 8471TriethylamineHCID 20157442HCID 20157442, 화합물

생성물 1

HCID 14032941HCID 14032941, 화합물수율 105.6%

시약·촉매·용매 1

HCID 6212Chloroform용매2회

실험 절차

To a mixture of 14.8 g of 2,6-dimethylimidazo[1,2-a]pyridine-3-carbohydrazide and 7.36 g of triethylamine in 300 ml of chloroform with stirring under cooling is added dropwise a solution of 8 g of chloroacetyl chloride in 50 ml of chloroform at 5°-10° C. After the mixture is stirred for 30 minutes, the reaction temperature is raised to room temperature and the resultant mixture is further stirred for 30 minutes. To the reaction mixture is added water and the precipitated crystals are collected by filtration to give 21 g of N'-chloroacetyl-2,6-dimethylimidazo[1,2-a]pyridine-3-carbohydrazide, melting at 290°-291° C. with decomposition.

후처리

  1. temperatureunder cooling
  2. stirringAfter the mixture is stirred for 30 minutes
  3. filtrationthe precipitated crystals are collected by filtration

출처 및 근거

ORD 기록
ord-94a175f3cb80439ab86365f7a7d91fdb
출처 데이터셋
uspto-grants-1987_12
특허 번호
US04713381

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