Cl.[NH2:2][CH2:3][C:4]([C:6]1[N:13]2[C:9]([S:10][CH:11]=[CH:12]2)=[N:8][C:7]=1[CH3:14])=[O:5].Cl[C:16]([O:18][CH2:19][CH3:20])=[O:17].C(OCC)(=O)C.C(=O)(O)[O-].[Na+]>O.C(Cl)(Cl)Cl>[CH2:19]([O:18][C:16]([NH:2][CH2:3][C:4]([C:6]1[N:13]2[C:9]([S:10][CH:11]=[CH:12]2)=[N:8][C:7]=1[CH3:14])=[O:5])=[O:17])[CH3:20]
To a solution of 4 g of 5-aminoacetyl-6-methylimidazo[2,1-b]thiazole hydrochloride in 50 ml of water is added a mixed solution of 3.2 g of ethyl chloroformate and 50 ml of ethyl acetate under stirring, and then 7.6 g of sodium bicarbonate is added. After the mixture is stirred at room temperature for 4 hours, chloroform and water are added to the resulting mixture. The chloroform layer is separated, washed with water and dried over magnesium sulfate, and then the chloroform is distilled off under reduced pressure. The residual oil is purified with a column chromatography using chloroform as a eluent to give 2 g of 5-ethoxycarbonylaminoacetyl-6-methylimidazo[2,1-b]thiazole.
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