Tetrahydrofuran → 1-Bromo-6,7-dihydroxyheptane
반응식
[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH:7]1[O:9][CH2:8]1.[O:10]1CCCC1.Cl(O)(=O)(=O)=O>O>[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH:7]([OH:9])[CH2:8][OH:10]참가 물질
5
실험 절차
42 g of 1-bromo-6,7-epoxyheptane were introduced into a mixture of 400 ml of tetrahydrofuran and 235 ml of water, which had been adjusted to pH 2 with perchloric acid, at room temperature. After stirring at room temperature for 8 hours, the mixture was neutralized, evaporated under reduced pressure and the residue was extracted with methylene chloride. After removal of the solvent, 41.5 g of crude 1-bromo-6,7-dihydroxyheptane were obtained.
후처리
- customevaporated under reduced pressure
- extractionthe residue was extracted with methylene chloride
- customAfter removal of the solvent
출처 및 근거
- ORD 기록
- ord-64d38b1a73e649d388df729d725bbb00
- 출처 데이터셋
- uspto-grants-1987_12
- 특허 번호
- US04713455
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