Hydrochloric Acid → 2-Amino-4-phenylbutyrate ethyl hydrochloride

HRID 986774

반응식

HRID 986774 반응식
[NH2:1][CH:2]([C:11]([OH:13])=[O:12])[CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[ClH:14].[CH2:15](O)[CH3:16]>>[ClH:14].[NH2:1][CH:2]([CH2:3][CH2:4][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1)[C:11]([O:13][CH2:15][CH3:16])=[O:12]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 102530Homophenylalanine, DL-

생성물 1

HCID 533952832-Amino-4-phenylbutyrate ethyl hydrochloride

실험 절차

A suspension of d,l-homophenylalanine (5 g., 27.9 mmole) in absolute ethanol (60 ml.) was cooled to 0° (ice bath) and saturated with hydrochloric acid gas. The mixture was allowed to warm to room temperature and stirred overnight. A stream of nitrogen was then passed through the solution to remove the bulk of the hydrochloric acid and the mixture was evaporated to dryness. The solid residue was triturated with ether, filtered and dried to give (±)-α-aminobenzenebutanoic acid, ethyl ester, monohydrochloride as a fluffy white solid; m.p. 129°-130°. Rf (acetic acid/methanol/dichloromethane; 1:1:8)=0.63.

후처리

  1. temperaturewas cooled to 0° (ice bath)
  2. customto remove the bulk of the hydrochloric acid
  3. customthe mixture was evaporated to dryness
  4. customThe solid residue was triturated with ether
  5. filtrationfiltered
  6. customdried

출처 및 근거

ORD 기록
ord-18d49c616b4e489b9d2506c44a303e72
출처 데이터셋
uspto-grants-1987_12
특허 번호
US04716155

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