4-Methylmorpholine → HCID 178427470, 화합물

HRID 986811

반응식

HRID 986811 반응식
[NH:1]([S:24]([C:27]1[CH:33]=[CH:32][C:30]([CH3:31])=[CH:29][CH:28]=1)(=[O:26])=[O:25])[CH2:2][C:3]([N:5]1[CH2:23][CH2:22][CH2:21][C@H:6]1[C:7]([NH:9][C@H:10]([C:18]([OH:20])=[O:19])[CH2:11][CH2:12][CH2:13][NH:14][C:15](=[NH:17])[NH2:16])=[O:8])=[O:4].ClC(OCC)=O.CN1CCOCC1.[CH:47]1[C:52]([OH:53])=[CH:51][C:50]2[O:54][C:55]3[C:61](=[N+:62]([O-:63])[C:49]=2[CH:48]=1)[CH:60]=[CH:59][C:57](=[O:58])[CH:56]=3>O1CCCC1>[NH:1]([S:24]([C:27]1[CH:28]=[CH:29][C:30]([CH3:31])=[CH:32][CH:33]=1)(=[O:26])=[O:25])[CH2:2][C:3]([N:5]1[CH2:23][CH2:22][CH2:21][C@H:6]1[C:7]([NH:9][C@H:10]([C:18]([OH:20])=[O:19])[CH2:11][CH2:12][CH2:13][NH:14][C:15](=[NH:16])[NH2:17])=[O:8])=[O:4].[CH:59]1[C:57]([OH:58])=[CH:56][C:55]2[O:54][C:50]3[C:49](=[N+:62]([O-:63])[C:61]=2[CH:60]=1)[CH:48]=[CH:47][C:52](=[O:53])[CH:51]=3

참가 물질

6

반응물 4

HCID 79724-MethylmorpholineHCID 10928Ethyl chloroformateHCID 11077ResazurinHCID 178427469HCID 178427469, 화합물

생성물 1

HCID 178427470HCID 178427470, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

반응 조건

온도
-10 °C

실험 절차

1 mmol of Tos-Gly-Pro-Arg-OH was suspended in 30 ml of tetrahydrofuran (dry). 4 mmol of ethyl chloroformate were added at room temperature, and the mixture was stirred for about 15 minutes and cooled to -10° C. 3 mmol of N-methylmorpholine were added and the mixture was stirred at room temperature for 60 minutes. 3 mmol of resazurin in 60 ml of desiccated tetrahydrofuran were then admixed dropwise. The reaction was complete after 4 h and the mixture was filtered and the filtrate was evaporated.

후처리

  1. stirringthe mixture was stirred at room temperature for 60 minutes
  2. waitThe reaction was complete after 4 h
  3. filtrationthe mixture was filtered
  4. customthe filtrate was evaporated

출처 및 근거

ORD 기록
ord-f09c513ba5ea4ca4a981bb3e3a3ec2f8
출처 데이터셋
uspto-grants-1987_12
특허 번호
US04716222

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