Diethyl Ether → HCID 178463964, 화합물

HRID 986849

반응식

HRID 986849 반응식
[NH2:1][CH:2]([CH2:4][CH2:5][CH2:6][C:7]([C:10]1[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][CH:11]=1)([CH3:9])[CH3:8])[CH3:3].[H][H].CCOCC>Cl>[NH2:1][CH:2]([CH2:4][CH2:5][CH2:6][C:7]([C@H:10]1[CH2:15][CH2:14][C@H:13]([NH2:16])[CH2:12][CH2:11]1)([CH3:9])[CH3:8])[CH3:3]

참가 물질

5

반응물 3

HCID 3283Diethyl EtherHCID 201566692-Amino-6-(4-aminophenyl)-6-methylheptaneHCID 178418361HCID 178418361, 화합물2회

생성물 1

HCID 178463964HCID 178463964, 화합물

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

5.0 Parts of 2-amino-6-(4-aminophenyl)-6-methylheptane dissolved in 68 parts of 1N aqueous hydrochloric acid were shaken at room temperature and atmospheric pressure with hydrogen in the presence of 0.5 parts of Nishimura catalyst (rhodium-platinum oxides). Hydrogen uptake ceased at 105% of theory and the solution was filtered free of catalyst and treated with sodium hydroxide solution to give an oil which was isolated with ether. After removing the ether the residue was distilled to give 4.0 parts of cis and trans-2-amino-6-(4-aminocyclohexyl)-6-methyl-heptane b0.3 120°-9° with the following percentage composition by weight.

후처리

  1. filtrationthe solution was filtered free of catalyst
  2. additiontreated with sodium hydroxide solution
  3. customto give an oil which
  4. customAfter removing the ether the residue
  5. distillationwas distilled

출처 및 근거

ORD 기록
ord-bbbe8691bcf548d4a8c7dcad54652f95
출처 데이터셋
uspto-grants-1987_12
특허 번호
US04716248

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