Hydrochloric Acid → HCID 13628314, 화합물

HRID 986873노트

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HRID 986873 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][CH2:11][C:12]([OH:14])=[O:13])=[CH:6][CH:5]=1)([O-])=O.O.Cl>C(O)C.CC(C)=O.[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([NH:10][CH2:11][C:12]([OH:14])=[O:13])=[CH:6][CH:5]=1

참가 물질

7

반응물 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 12095Glycine, N-(4-nitrophenyl)-

생성물 1

HCID 13628314HCID 13628314, 화합물수율 114.3%

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 180Acetone용매HCID 702Ethanol용매

실험 절차

1 g (5 mmol) of (4-nitrophenyl)glycine is dissolved in 20 ml of ethanol, 5 ml of water and 2.5 ml (2.5 eq) of 5N hydrochloric acid in a 250 ml glass reactor (Paar apparatus). 1 g of palladium-on-charcoal (50% moisture and 10% active) is then introduced. The mixture is hydrogenated under a pressure of approximately 2.76×105 Pa for 1 hour 30 minutes at a temperature of 20° C. After filtering through celite, the filtrate is evaporated to dryness. A white solid is obtained which is taken up in 50 ml of acetone, filtered and dried under vacuum at 40° C. 0.95 g of a white powder is obtained.

후처리

  1. filtrationAfter filtering through celite
  2. customthe filtrate is evaporated to dryness
  3. customA white solid is obtained which
  4. filtrationfiltered
  5. customdried under vacuum at 40° C

출처 및 근거

ORD 기록
ord-1ad1bbc28b9c497484ac875239a4cd45
출처 데이터셋
uspto-grants-2003_10
특허 번호
US06630004B1

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