Sodium Hydroxide → 5-Carboxy-2-(4-fluorophenyl)-3-(pyridin-4-yl)thiophene

HRID 9879

반응식

HRID 9879 반응식
C([O:3][C:4]([C:6]1[S:10][C:9]([C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)=[C:8]([C:18]2[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=2)[CH:7]=1)=[O:5])C.[OH-].[Na+]>C(O)C>[C:4]([C:6]1[S:10][C:9]([C:11]2[CH:12]=[CH:13][C:14]([F:17])=[CH:15][CH:16]=2)=[C:8]([C:18]2[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=2)[CH:7]=1)([OH:5])=[O:3]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 219885075-Ethoxycarbonyl-2-(4-fluorophenyl)-3-(pyridin-4-yl)thiophene

생성물 1

HCID 219885025-Carboxy-2-(4-fluorophenyl)-3-(pyridin-4-yl)thiophene수율 91.2%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
100 °C

실험 절차

5-Ethoxycarbonyl-2-(4-fluorophenyl)-3-(pyridin-4-yl)thiophene (15.17 g (46.3 mmol), prepared as described in 1)) was dissolved in ethanol (150 ml). To the solution was added an aqueous solution of 1 N sodium hydroxide (93 ml, 93 mmol), and the resulting mixture was stirred at 100° C. for 30 minutes. At the end of this time, ethanol was removed by distillation under reduced pressure. To the reaction residue was added water, and then an aqueous solution of 1 N hydrochloric acid (93 ml). The precipitated crystals were collected by filtration, to give the title compound (12.64 g) as a pale brown powder (yield 91%).

후처리

  1. customAt the end of this time, ethanol was removed by distillation under reduced pressure
  2. additionTo the reaction residue was added water
  3. filtrationThe precipitated crystals were collected by filtration

출처 및 근거

ORD 기록
ord-d7ef2be036f64ada85c82b1e0ea6db93
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07091352B2

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