1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 10216398, 화합물

HRID 988289노트

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HRID 988289 반응식
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH2:8][CH:9]([N:13]([CH:17]3[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]3)[CH2:14][CH2:15][CH3:16])[CH2:10]2)=[CH:5][CH:4]=1.[C:23]([N:26]1[CH2:31][CH2:30]C(C(O)=O)[CH2:28][CH2:27]1)(=[O:25])C.CCN=C=NCCCN(C)C.C1C=CC2N([OH:55])N=NC=2C=1>CCN(C(C)C)C(C)C>[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH2:8][CH:9]([N:13]([CH2:14][CH2:15][CH3:16])[CH:17]3[CH2:18][CH2:19][N:20]([C:23]([N:26]4[CH2:27][CH2:28][O:55][CH2:30][CH2:31]4)=[O:25])[CH2:21][CH2:22]3)[CH2:10]2)=[CH:5][CH:4]=1

참가 물질

6

반응물 4

HCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 1172551-Acetylpiperidine-4-carboxylic acidHCID 12135182(7-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-piperidin-4-yl-propyl-amine

생성물 1

HCID 10216398HCID 10216398, 화합물

시약·촉매·용매 1

HCID 81531Diisopropylethylamine용매

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온도
25 °C

실험 절차

To a solution of (7-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-piperidin-4-yl-propyl-amine (200 μL of 0.25 M in dimethyl formamide, 50 μmole) was added 1-acetylpiperidine-4-carboxylic acid (220 μL of 0.25M in DMF), 300 μL of EDCI (0.25M in DMF) and 220 uL of HOBT (0.25M in DMF) and 30 μL DIEA. The solution was allowed to stir for 48 h at 25° C. under N2. Concentrated in vacuo. The final product was isolated by preparative RPHPLC (YMC Combiprep ODS-A column, 10-90% acetonitrile: water (0.1% TFA)) to afford 1-(4-{4-[(7-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-propyl-amino]-piperidine-1-carbonyl}-piperidin-1-yl)-ethanone 2 (5.2 mg ), [M+H]+=456.

후처리

  1. concentrationConcentrated in vacuo

출처 및 근거

ORD 기록
ord-332abbc027d94324baedba80f0b58fcb
출처 데이터셋
uspto-grants-2003_10
특허 번호
US06635658B2

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