Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(3,4-Dichlorophenyl)methanesulfonyl chloride → 4-[{2-[1-benzhydryl-5-chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1H-indol-3-yl]ethyl}(methyl)amino]benzoic Acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (3,4-Dichlorophenyl)methanesulfonyl chloride | HCID 2794622 | — |
| 반응물 | 4-({2-[2-(2-Amino-ethyl)-1-benzhydryl-5-chloro-1H-indol-3-yl]-ethyl}methyl-amino)-benzoic acid methyl ester | HCID 20598525 | — |
| 생성물 | 4-[{2-[1-benzhydryl-5-chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1H-indol-3-yl]ethyl}(methyl)amino]benzoic Acid | HCID 21962384 | 87% |
반응 단계
The intermediate from example 146 step 7 was treated with 3,4-dichlorophenylmethanesulfonylchloride according to the procedure in Example 87 step 2 to generate the desired product in 87% yield.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06635771B2 |
| 출처 데이터셋 | uspto-grants-2003_10 |
| ORD ID | ord-c889b974a87d4c79968147d2c09825dc |
| 출처 메모 | uspto-grants-2003_10 |