HRID988910

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2794622

(3,4-Dichlorophenyl)methanesulfonyl chloride

C7H5Cl3O2S

结构：COC(=O)c1ccc(N(C)CCc2c(CCN)n(C(c3ccccc3)c3ccccc3)c3ccc(Cl)cc23)cc1

HCID20598525

未命名化合物

PRODUCTS

生成物

结构：CN(CCc1c(CCNS(=O)(=O)Cc2ccc(Cl)c(Cl)c2)n(C(c2ccccc2)c2ccccc2)c2ccc(Cl)cc12)c1ccc(C(=O)O)cc1

HCID21962384

未命名化合物

收率 87%

PROCEDURE

实验过程

The intermediate from example 146 step 7 was treated with 3,4-dichlorophenylmethanesulfonylchloride according to the procedure in Example 87 step 2 to generate the desired product in 87% yield.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c889b974a87d4c79968147d2c09825dc
来源数据集: uspto-grants-2003_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06635771B2
来源说明: uspto-grants-2003_10

反应 SMILES

C[O:2][C:3](=[O:40])[C:4]1[CH:9]=[CH:8][C:7]([N:10]([CH2:12][CH2:13][C:14]2[C:22]3[C:17](=[CH:18][CH:19]=[C:20]([Cl:23])[CH:21]=3)[N:16]([CH:24]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[C:15]=2[CH2:37][CH2:38][NH2:39])[CH3:11])=[CH:6][CH:5]=1.[Cl:41][C:42]1[CH:43]=[C:44]([CH2:49][S:50](Cl)(=[O:52])=[O:51])[CH:45]=[CH:46][C:47]=1[Cl:48]>>[CH:24]([N:16]1[C:17]2[C:22](=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)[C:14]([CH2:13][CH2:12][N:10]([CH3:11])[C:7]2[CH:8]=[CH:9][C:4]([C:3]([OH:2])=[O:40])=[CH:5][CH:6]=2)=[C:15]1[CH2:37][CH2:38][NH:39][S:50]([CH2:49][C:44]1[CH:45]=[CH:46][C:47]([Cl:48])=[C:42]([Cl:41])[CH:43]=1)(=[O:52])=[O:51])([C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1)[C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1