Tetrahydrothiophene → 1-(3,3-Dimethyl-2-oxobutyl)thiolan-1-ium bromide

HRID 988945

반응식

HRID 988945 반응식
[S:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[Br:6][CH2:7][C:8](=[O:13])[C:9]([CH3:12])([CH3:11])[CH3:10]>CC(C)=O>[Br-:6].[O:13]=[C:8]([C:9]([CH3:12])([CH3:11])[CH3:10])[CH2:7][S+:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 1127TetrahydrothiopheneHCID 21642Bromopinacolone

생성물 1

HCID 225645781-(3,3-Dimethyl-2-oxobutyl)thiolan-1-ium bromide수율 85%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

Using the 100-millilitter 3-port flask, 2 grams of tetrahydrothiophene was dissolved in 20 milli-litter of acetone. 4.87 grams of 1-bromo-3,3-dimethyl-2-butanone was dropped into the solution over agitation. After 24 hours, white crystal was precipitated, and was filtrated. The white crystal was pulverized, and was washed in ether. The pulverized white crystal was dried at 30 degrees in centigrade for 6 hours by using a low-pressure drier. 5.15 grams of 2-oxo-3,3-dimethylbutyl-thiacyclopentanium bromide was obtained. The yield was 75.0%.

후처리

  1. customwhite crystal was precipitated
  2. filtrationwas filtrated
  3. washwas washed in ether
  4. customThe pulverized white crystal was dried at 30 degrees in centigrade for 6 hours

출처 및 근거

ORD 기록
ord-6edaecb22a8f4b71b53e7e8dd3d76215
출처 데이터셋
uspto-grants-2003_10
특허 번호
US06638685B2

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