Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acrylonitrile → 2-Benzyl-5-cyanoethyl-2,5-diazabicyclo[2.2.1]heptane
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acrylonitrile | HCID 7855 | — |
| 반응물 | 2-Benzyl-2,5-diazabicyclo[2.2.1]heptane | HCID 562932 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 2-Benzyl-5-cyanoethyl-2,5-diazabicyclo[2.2.1]heptane | HCID 54191608 | 89.2% |
반응 단계
Freshly distilled acrylonitrile (2.5 g) is added to a solution of 3 g of 2-benzyl-2,5-diazabicyclo [2.2.1]heptane in 40 mL of anhydrous toluene and refluxed with vigorous stirring. The solution was cooled, filtered and evaporated. Bulb tube distillation (boiling point: 120°-130° C. at 0.01 mbar) resulted in 3.43 g of 142 as a colorless oil (88% of the theoretical yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06638925B2 |
| 출처 데이터셋 | uspto-grants-2003_10 |
| ORD ID | ord-9ce6fa56805d4ab4915474ae422fc1cf |
| 출처 메모 | uspto-grants-2003_10 |