Methyl p-toluenesulfonate → 2-Fluoro-1-methylpyridinium p-toluenesulfonate

반응식

[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:8][C:9]1[CH:14]=[CH:13][C:12]([S:15]([O:18]C)(=[O:17])=[O:16])=[CH:11][CH:10]=1>>[CH3:8][C:9]1[CH:10]=[CH:11][C:12]([S:15]([O-:18])(=[O:17])=[O:16])=[CH:13][CH:14]=1.[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N+:3]=1[CH3:8]

참가 물질

반응물 2

HCID 6645Methyl p-toluenesulfonate

HCID 97462-Fluoropyridine

생성물 1

HCID 1716312-Fluoro-1-methylpyridinium p-toluenesulfonate

반응 조건

온도: 70 °C

실험 절차

10 mmol of 2-fluoropyridine and 10 mmol of methyl 4-methylbenzenesulphonate are mixed in a 50 ml round-bottomed flask and stirred for 6 hours at 70° C. under a nitrogen atmosphere. The salt obtained in the form of a white solid is used without additional purification in the following step.

후처리

customThe salt obtained in the form of a white solid
customis used without additional purification in the following step

출처 및 근거

ORD 기록: ord-69e889f052d14059a99a12de8bf46d29
출처 데이터셋: uspto-grants-2003_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06638946B2

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