2,4-Dichloroaniline → 4-(2,4-Dichloroanilino)-7-methoxybenzo[g]quinoline-3-carbonitrile

HRID 989344

반응식

HRID 989344 반응식
[Cl:1][C:2]1[CH:8]=[C:7]([Cl:9])[CH:6]=[CH:5][C:3]=1[NH2:4].[H-].[Na+].Cl[C:13]1[C:22]2[C:17](=[CH:18][C:19]3[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][C:20]=3[CH:21]=2)[N:16]=[CH:15][C:14]=1[C:29]#[N:30]>CN(C=O)C>[Cl:1][C:2]1[CH:8]=[C:7]([Cl:9])[CH:6]=[CH:5][C:3]=1[NH:4][C:13]1[C:22]2[C:17](=[CH:18][C:19]3[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][C:20]=3[CH:21]=2)[N:16]=[CH:15][C:14]=1[C:29]#[N:30]

참가 물질

5

반응물 3

HCID 111232,4-DichloroanilineHCID 24758Sodium hydrideHCID 98351404-Chloro-7-methoxybenzo[g]quinoline-3-carbonitrile

생성물 1

HCID 219563924-(2,4-Dichloroanilino)-7-methoxybenzo[g]quinoline-3-carbonitrile수율 86.2%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

According to the procedure of Example 14, a reaction mixture of 657.8 mg (4.06 mmol) of 2,4-dichloroaniline and 162.4 mg (4.06 mmol) of sodium hydride in 18 mL of anhydrous DMF is stirred at room temperature for 0.5 hour. To the mixture is added 494.0 mg (1.84 mmol) of 4-chloro-7-methoxybenzo[g]quinoline-3-carbonitrile. The resulting mixture is heated at 55° C. for 1 hour. After work up, 624.6 mg (86.2%) of 4-(2,4-dichloroanilino)-7-methoxybenzo[g]quinoline-3-carbonitrile is obtained as a yellow solid, mp 215-217° C.

후처리

  1. temperatureThe resulting mixture is heated at 55° C. for 1 hour

출처 및 근거

ORD 기록
ord-5ba700de3a0949408425f35b46cbb269
출처 데이터셋
uspto-grants-2003_10
특허 번호
US06638929B2

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