Boron Trichloride → Raloxifene Bismethyl Ether (hydrochloride)

HRID 989803

반응식

HRID 989803 반응식
B(Cl)(Cl)[Cl:2].[CH3:5][O:6][C:7]1[CH:8]=[CH:9][C:10]2[C:14]([C:15](=[O:31])[C:16]3[CH:21]=[CH:20][C:19]([O:22][CH2:23][CH2:24][N:25]4[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]4)=[CH:18][CH:17]=3)=[C:13]([C:32]3[CH:37]=[CH:36][C:35]([O:38][CH3:39])=[CH:34][CH:33]=3)[S:12][C:11]=2[CH:40]=1>C(Cl)Cl>[ClH:2].[CH3:5][O:6][C:7]1[CH:8]=[CH:9][C:10]2[C:14]([C:15](=[O:31])[C:16]3[CH:17]=[CH:18][C:19]([O:22][CH2:23][CH2:24][N:25]4[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]4)=[CH:20][CH:21]=3)=[C:13]([C:32]3[CH:37]=[CH:36][C:35]([O:38][CH3:39])=[CH:34][CH:33]=3)[S:12][C:11]=2[CH:40]=1

참가 물질

4

반응물 2

HCID 25135Boron TrichlorideHCID 10767755Raloxifene Bismethyl Ether

생성물 1

HCID 45260096Raloxifene Bismethyl Ether (hydrochloride)

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
22.5 °C

실험 절차

A mixture of the compound prepared as described in Preparation 1 (8.46 grams) and the acid chloride prepared as described in Preparation 3 (10.0 grams) in methylene chloride (350 mL) was cooled to about 20-25° C. The cool mixture was treated with boron trichloride (2.6 mL), and the resulting mixture mechanically stirred. The reaction was monitored by HPLC using the assay described above. After 85 minutes, the in situ HPLC yield based on a 6-methoxy-2-(4-methoxyphenyl)-3-[4-(2-piperidinoethoxy)benzoyl]benzo[b]thiophene standard was 88%.

후처리

  1. additionA mixture of the compound
  2. customprepared
  3. customthe in situ HPLC yield

출처 및 근거

ORD 기록
ord-1e25909ca3c341a2bdb0cddc8aeb31ff
출처 데이터셋
uspto-grants-2002_10
특허 번호
US06458811B1

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